We developed a novel isomorphic cytidine nucleoside where deamination to the uridine analogue by cytidine deaminase (CDA) yields a fluorescence output. We then used this assay to identify novel CDA inhibitors. Read more in ACS Chem. Biol. here. 

We report a new fluorescence polarization-based assay to measure the binding of ligands to SARS-CoV-2 main protease (Mpro). Read more in ACS Pharmacol. Transl. Sci. (pdf).

Differences in sugar conformation affect how APOBEC3A and APOBEC3B enzymes recognize nucleic acids and catalyze C-to-U deamination. See our new work in ACS Chem. Biol. (pdf).

Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).

Congratulations to Katherine and our collaborators for their ACS Med. Chem. Lett. manuscript on APOBEC3A stability with mutations to the catalytic glutamic acid! [pdf]