We developed a novel isomorphic cytidine nucleoside where deamination to the uridine analogue by cytidine deaminase (CDA) yields a fluorescence output. We then used this assay to identify novel CDA inhibitors. Read more in ACS Chem. Biol. here. 

We report a new fluorescence polarization-based assay to measure the binding of ligands to SARS-CoV-2 main protease (Mpro). Read more in ACS Pharmacol. Transl. Sci. (pdf).

Differences in sugar conformation affect how APOBEC3A and APOBEC3B enzymes recognize nucleic acids and catalyze C-to-U deamination. See our new work in ACS Chem. Biol. (pdf).

Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).

Congratulations to Jared and Michael for their recent publication on the development of allosteric NIK-binding fragments in ACS Med Chem Lett (link).