Archive of Harki Laboratory News

Differences in sugar conformation affect how APOBEC3A and APOBEC3B enzymes recognize nucleic acids and catalyze C-to-U deamination. See our new work in ACS Chem. Biol. (pdf).

Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).

Congratulations to Jared and Michael for their recent publication on the development of allosteric NIK-binding fragments in ACS Med Chem Lett (link).

Congratulations to Katherine and our collaborators for their ACS Med. Chem. Lett. manuscript on APOBEC3A stability with mutations to the catalytic glutamic acid! [pdf]

Congratulations to Sam, Ram and Ruben for their publication in Chem. Eur. J. revealing new CRDD monomers that mimic pyrimidines.[pdf]