The role of sugar pucker on nucleic acid recognition by APOBEC3A and APOBEC3B
Published on 2025-02-05 by daharki
Differences in sugar conformation affect how APOBEC3A and APOBEC3B enzymes recognize nucleic acids and catalyze C-to-U deamination. See our new work in ACS Chem. Biol. (pdf).
New Manuscript in Cell Chemical Biology
Published on 2025-02-06 by daharki
Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).
New publication in ACS Med Chem Lett
Published on 2023-11-04 by daharki
Congratulations to Jared and Michael for their recent publication on the development of allosteric NIK-binding fragments in ACS Med Chem Lett (link).
New publication in ACS Med Chem Lett
Published on 2023-02-27 by daharki
Congratulations to Katherine and our collaborators for their ACS Med. Chem. Lett. manuscript on APOBEC3A stability with mutations to the catalytic glutamic acid! [pdf]
Expanding Catch and Release DNA Decoys (CRDDs)
Published on 2022-08-28 by daharki
Congratulations to Sam, Ram and Ruben for their publication in Chem. Eur. J. revealing new CRDD monomers that mimic pyrimidines.[pdf]