Harki Laboratory

Medicinal Chemistry • Synthesis • Drug Development

chemical structure on top of dna
Harki Lab 2024
Harki Lab Research Interests

Lab Announcements

New Manuscript in Cell Chemical Biology

HLB-0532259 induces Aurora kinase A and N-Myc degradation.

Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).

Research Interests

Research in the Harki laboratory focuses on the design, synthesis and biological characterization of novel small molecules, peptides, and oligonucleotides that influence cellular function. We frequently pursue projects involving the development of chemical matter against nucleic acid-interacting proteins for applications in anticancer and antiviral drug discovery.  

Our core science is organic chemistry. We also use techniques of modern biochemistry, biophysics, and cellular/molecular biology to evaluate the biological activities of the compounds we synthesize. Our group aspires to develop efficacious and safe compounds with developmental potential.

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