Lab Announcements
A Novel Fluorescence-based Assay to Develop Cytidine Deaminase Inhibitors
Published on 2025-11-27 by daharki
We developed a novel isomorphic cytidine nucleoside where deamination to the uridine analogue by cytidine deaminase (CDA) yields a fluorescence output. We then used this assay to identify novel CDA inhibitors. Read more in ACS Chem. Biol. here.
New Assay to Measure Ligand Binding to SARS-CoV-2 Main Protease (Mpro)
Published on 2025-11-27 by daharki
We report a new fluorescence polarization-based assay to measure the binding of ligands to SARS-CoV-2 main protease (Mpro). Read more in ACS Pharmacol. Transl. Sci. (pdf).
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