Medicinal Chemistry • Synthesis • Drug Development

Lab Announcements
The role of sugar pucker on nucleic acid recognition by APOBEC3A and APOBEC3B
Published on 2025-02-05 by daharki

Differences in sugar conformation affect how APOBEC3A and APOBEC3B enzymes recognize nucleic acids and catalyze C-to-U deamination. See our new work in ACS Chem. Biol. (pdf).
New Manuscript in Cell Chemical Biology
Published on 2025-02-06 by daharki

Targeted degradation of Aurora kinase A results in degradation of N-Myc in pediatric neuroblastoma. See our work in Cell Chem. Biol. (pdf).